Table 2.

In silico evaluation of five novel mutations

Gene	DNA change	Protein change	Mutation taster	PolyPhen-2	SIFT	MAF (gnomAD)
RAF1	c.786 T > G	p.N262K	Disease-causing	Probably damaging	Deleterious	–
RAF1	c.788 T > G	p.V263G	Disease-causing	Probably damaging	Deleterious	–
BRAF	c.1796C > T	p.T599I	Disease-causing	Probably damaging	Deleterious	–
LZTR1	c.509G > C	p.R170P	Disease-causing	Probably damaging	Deleterious	–
LZTR1	c.2374 T > G	p.C792G	Disease-causing	Probably damaging	Deleterious	–