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. 2019 Feb 7;20:118. doi: 10.1186/s12864-019-5465-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — GP63 general gene features. The scheme highlights conserved elements found on most GP63 sequences, such as the signal peptide, propeptide, zinc-binding motif [8], multiple cysteine residues, the GPI anchor site and a nearly universally conserved motif of seven consecutive amino acids we named KDELMAP. The PCR strategy used to amplify the GP63 genes is also shown with products varying from 1 Kb (up to the KDELMAP region) and 1,6 Kb (finishing on the GPI anchor site)