Fig. 2.

Genomic organization of Leishmania GP63 genes. Genomic organization of GP63 genes from Leishmanis sp., showing the general distribution, location and synteny of these genes along chromosomes 10, 28 and 31. a Synteny analysis on chromosome 28 showing the localization of the GP63 gene in L. major and L. infantum and its absence in the equivalent position from the L. braziliensis chromosome 28. b Distribution of GP63 genes in Leishmania sp., chromosome 31. Pseudogenes from the L. braziliensis genome are highlighted in gray. c Expansion of GP63 genes in the L. braziliensis chromosome 10, when compared to L. major and L. infantum, within the same chromosome position, as indicated by the flanking genes on the left (some unrelated genes are also included). The horizontal arrows indicate the transcription sense of the genes and the yellow, black and red colors define the 3’ UTR groups identified for the L. major and L. infantum genes. The diagram for L. infantum does not include the preliminary annotation derived from the recent resequencing of its genome [30]. For the L. braziliensis genes, identical colors group those with similar 3’UTRs, as classified in Table 1