Fig. 5.

Leishmania major, L. infantum and L. braziliensis C-terminal alignments and groups. Alignment showing the difference in the C-terminuses of the chromosome 10 GP63 sequences having divergent 3’ UTRs. a and b shows the L. major and L. infantum C-terminus sequences, respectively, their groups based on their expression profiles and the predicted GPI anchor site (boxed in green). The motif identified in the constitutively expressed L. infantum group 1 sequence also found in the L. braziliensis group 1 C-terminus is boxed in red, while the motif found in the L. infantum and L. major stage specific genes from Groups 2 and 3 nearly identical to a similar motif from the L. braziliensis group 3 genes is boxed in orange. c Alignment of the C-terminal ends of the different L. braziliensis chromosome 10, with the grouping described in the text and the conserved elements also seen in L. major and L. infantum indicated as for A and B