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. 2019 Feb 7;7:35. doi: 10.1186/s40425-018-0491-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — The influence of pre- and post-ASCT MDSC phenotypes on in vitro melphalan-induced cytotoxic assay. MM cell line, IM-9 cells (a) or primary MM cells (b) were cultured with or without MDSCs isolated from pre- and post-ASCT samples (MM cell:MDSC ratio 1:1) in the presence of human M-CSF. The top figures are representative staining with Annexin V-APC and PI after incubation with or without melphalan. In the bottom figure, individual data from independent melphalan-induced cytotoxic assay by E- and M-MDSC phenotypes isolated from five patients were compared. The label of post-ASCT MDSCs on the figure means the cells expressing each MDSC phenotype. The data are presented as the mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001