Figure 3. . Ultrasound-induced endosomal escape of aluminum phthalocyanine disulfonate.
Fluorescence microscopy verified the uptake and intracellular localization of the sonosensitizers (FOV: 40 μm). (A) Photosensitizer (red) was taken up in F98 cells and localized in granular organelles, that is, endosomes/lysosomes; (B) One hour post ultrasound exposure. The diffuse AlPcS2a fluorescence throughout the cytosol indicates an induced endosomal escape of the photosensitizer by sonication.
AlPcS2a: Aluminum phthalocyanine disulfonate.
Reproduced with permission from [42].