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. 2019 Feb 7;11:20. doi: 10.1186/s13148-019-0612-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — DNA methylation in the promoter region of the LEPR gene. a A schematic representation of the LEPR gene, including the CpG islands in the promoter region. b The methylation pattern in the LEPR promoter on the fetal and maternal sides of third-trimester placental biopsies from the control group. c The % methylation level in the LEPR promoter region from third-trimester placenta. DNA was extracted from third-trimester placental biopsies (on the fetal and maternal sides) in the control and obese women. After bisulfite treatment, the methylation level was determined by pyrosequencing. The data are quoted as the mean ± SEM. Statistical significance was assessed in a Friedman test