Fig. 1.

p53 mutation promoted metastasis and reduced the survival time of NSCLC patients. a) The mutation frequency of p53 codons in 78 NSCLC tissues. The mutational events of p53 codons b) and representative mutation c) were shown. d Analysis of p53 mutation in metastatic (lymph node metastasis and distant organ metastasis) and non-metastatic tissues from human lung cancer. e Correlation of p53 (wt-p53 and mut-p53) with or without radiotherapy and the overall survival time of the NSCLC patients were shown. Survival curves were constructed using the Kaplan-Meier method and analyzed by the log-rank test. *, P < 0.05