Fig. 4.

Tumor classification and functional enrichment analysis with the 9 most frequently appearing 5’isomiRs. a Tumor classification. Y-axis is the average sensitivity for 1000 randomly produced test sets. “a” is the 9 most frequently appearing 5’isomiRs. In the list of 9 most frequently appearing 5’isomiRs, two 5’isomiRs were from hsa-miR-10b-5p and three 5’isomiRs belonged to has-375. “b” is obtained from “a” by removing three 5’isomiRs which had different 5′ loci from the canonical miRNA (one was from hsa-miR-10b-5p and two belonged to has-375). b Bar plot shows the enriched GO terms from DAVID functional annotation analysis. The clusters integrated with enrichment score are shown as Y-axis. The –log10(P-value after correlation) is plotted on the X-axis