Table 6.

Generalized Linear Mixed Model details

	Fixed effect	B	SE	P value	95% Confidence Interval
					Lower	Upper
EDSS	Baseline^	- 0.169	0.049	0.001 *	−0.266	− 0.071
	No neurological symptoms^^	- 0.671	0.080	<  0.0005 *	−0.829	−0.512
	Symptoms 10 years or shorter^^	- 0.127	0.078	0.106	−0.281	0.028
ALDS	Baseline^	- 0.023	0.032	0.468	−0.086	0.040
	No neurological symptoms^^	0.170	0.066	0.012 *	0.038	0.302
	Symptoms 10 years or shorter^^	0.106	0.067	0.116	−0.027	0.239
	Age at examination	- 0.004	0.002	0.045 *	−0.009	− 0.000
SF-36: PF	Baseline^	- 0.003	0.028	0.912	−0.060	0.053
	No neurological symptoms^^	0.363	0.075	<  0.0005 *	0.215	0.511
	Symptoms 10 years or shorter^^	0.258	0.090	0.005 *	0.080	0.435
SF-36: PCS	Baseline^	0.010	0.033	0.765	−0.055	0.075
	No neurological symptoms^^	0.281	0.072	<  0.0005 *	0.137	0.424
	Symptoms 10 years or shorter^^	0.177	0.089	0.050 *	0.000	0.353

A higher EDSS score indicates higher disability. A lower ALDS score indicates higher disability. A lower physical functioning and physical component summary score indicates lower quality of life. ^ = Reference group is the follow-up visit; ^^ = Reference group is neurological symptoms > 10 years; * indicates a significant p value; B = coefficient; ALDS = AMC Linear Disability Scale; EDSS = Expanded Disability Status Scale; PCS = physical component summary; PF = physical functioning; SE = standard error; SF-36 = Short Form (36) Health Survey