Table 4:
All grades adverse events of all patients (N = 83)
| Adverse Events: N (%) | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Total |
|---|---|---|---|---|---|
| Abdominal pain | 2 (2) | 2 (2) | |||
| Acute kidney injury | 1 (1) | 1 (1) | 2 (2) | ||
| Alanine aminotransferase increased | 17 (20) | 2 (2) | 1 (1) | 20 (24) | |
| Albumin | 6 (7) | 2 (2) | 8 (10) | ||
| Alkaline phosphatase increased | 2 (2) | 2 (2) | |||
| Allergic reaction | 2 (2) | 2 (2) | |||
| Alopecia | 35 (42) | 9 (11) | 44 (53) | ||
| Anemia | 41 (49) | 9 (11) | 2 (2) | 52 (63) | |
| Anorexia | 16 (19) | 5 (6) | 21 (25) | ||
| Aspartate aminotransferase increased | 12 (14) | 1 (1) | 13 (16) | ||
| Atrial fibrillation | 1 (1) | 1 (1) | |||
| Blood Bilirubin Increased | 5 (6) | 3 (4) | 8 (10) | ||
| Blurred vision | 2 (2) | 2 (2) | |||
| Bronchial infection | 1 (1) | 1 (1) | 2 (2) | ||
| Cardiac disorders - Other, specify | 1 (1) | 1 (1) | |||
| CD4 lymphocytes decreased | 1 (1) | 1 (1) | |||
| Chest wall pain | 1 (1) | 1 (1) | |||
| Chills | 3 (4) | 3 (4) | |||
| Cognitive disturbance | 1 (1) | 2 (2) | 1 (1) | 4 (5) | |
| Confusion | 1 (1) | 1 (1) | |||
| Conjunctivitis | 1 (1) | 1 (1) | |||
| Constipation | 19 (23) | 7 (8) | 26 (31) | ||
| Creatinine Increased | 6 (7) | 2 (2) | 8 (10) | ||
| Dehydration | 1 (1) | 1 (1) | 2 (2) | ||
| Dermatitis radiation | 20 (24) | 20 (24) | |||
| Diarrhea | 3 (4) | 1 (1) | 4 (5) | ||
| Disseminated intravascular coagulation | 1 (1) | 1 (1) | |||
| Dizziness | 1 (1) | 1 (1) | 1 (1) | 3 (4) | |
| Dry skin | 4 (5) | 4 (5) | |||
| Dysgeusia | 5 (6) | 1 (1) | 6 (7) | ||
| Dyspepsia | 1 (1) | 1 (1) | 2 (2) | ||
| Dysphagia | 1 (1) | 1 (1) | |||
| Dysphasia | 1 (1) | 1 (1) | 1 (1) | 3 (4) | |
| Dyspnea | 1 (1) | 1 (1) | |||
| Ear and labyrinth disorders - Other, specify | 2 (2) | 1 (1) | 3 (4) | ||
| Ear pain | 2 (2) | 2 (2) | |||
| Edema cerebral | 1 (1) | 1 (1) | |||
| Epistaxis | 3 (4) | 3 (4) | |||
| Erythema multiforme | 2 (2) | 2 (2) | |||
| Eye disorders - Other, specify | 2 (2) | 1 (1) | 3 (4) | ||
| Fall | 1 (1) | 1 (1) | |||
| Fatigue | 33 (40) | 27 (33) | 4 (5) | 64 (77) | |
| Fever | 2 (2) | 1 (1) | 3 (4) | ||
| Flatulence | 1 (1) | 1 (1) | |||
| Flu like symptoms | 1 (1) | 1 (1) | 2 (2) | ||
| Flushing | 1 (1) | 1 (1) | 2 (2) | ||
| Gait disturbance | 1 (1) | 1 (1) | |||
| Gastritis | 1 (1) | 1 (1) | |||
| Gastrointestinal disorders - Other, specify | 1 (1) | 1 (1) | |||
| Generalized muscle weakness | 2 (2) | 2 (2) | 4 (5) | ||
| Headache | 13 (16) | 9 (11) | 1 (1) | 23 (28) | |
| Hearing impaired | 1 (1) | 1 (1) | |||
| Hoarseness | 1 (1) | 1 (1) | |||
| Hyperkalemia | 1 (1) | 1 (1) | 2 (2) | ||
| Hypersomnia | 1 (1) | 1 (2) | |||
| Hypertension | 3 (4) | 1 (1) | 4 (5) | ||
| Hypokalemia | 4 (5) | 1 (1) | 1 (1) | 6 (7) | |
| Hypomagnesemia | 1 (1) | 1 (1) | |||
| Hyponatremia | 3 (4) | 3 (4) | |||
| Hypotension | 1 (1) | 1 (1) | |||
| Hypoxia | 1 (1) | 1 (1) | |||
| Infections and infestations - Other, specify | 1 (1) | 1 (1) | |||
| Infusion related reaction | 4 (5) | 4 (5) | |||
| Infusion site extravasation | 1 (1) | 1 (1) | |||
| Injection site reaction | 3 (4) | 3 (4) | |||
| Insomnia | 1 (1) | 1 (1) | |||
| Lethargy | 3 (4) | 3 (4) | |||
| Localized edema | 1 (1) | 1 (1) | |||
| Lymphocyte count decreased | 4 (5) | 4 (5) | |||
| Memory impairment | 3 (4) | 2 (2) | 5 (6) | ||
| Mucosal infection | 2 (2) | 2 (2) | |||
| Mucositis oral | 1 (1) | 1 (1) | |||
| Muscle weakness left-sided | 1 (1) | 1 (1) | |||
| Myalgia | 1 (1) | 1 (1) | |||
| Nasal congestion | 2 (2) | 2 (2) | |||
| Nausea | 26 (31) | 7 (8) | 2 (2) | 35 (42) | |
| Nervous system disorders - Other, specify | 1 (1) | 1 (1) | |||
| Neutrophil Count Decreased | 4 (5) | 9 (11) | 3 (4) | 5 (6) | 21 (25) |
| Olfactory nerve disorder | 1 (1) | 1 (1) | |||
| Otitis media | 1 (1) | 1 (1) | |||
| Pain | 2 (2) | 2 (2) | |||
| Paresthesia | 2 (2) | 2 (2) | |||
| Peripheral motor neuropathy | 1 (1) | 1 (1) | |||
| Platelet Count Decreased | 40 (48) | 6 (7) | 4 (5) | 11 (13) | 61 (73) |
| Pruritus | 3 (4) | 3 (4) | 6 (7) | ||
| Radiation recall reaction (dermatologic) | 1 (1) | 1 (1) | |||
| Rash acneiform | 4 (5) | 1 (1) | 5 (6) | ||
| Rash maculo-papular | 1 (1) | 1 (1) | 3 (4) | 5 (6) | |
| Rash pustular | 1 (1) | 1 (1) | |||
| Respiratory, thoracic and mediastinal disorders - Other, specify | 1 (1) | 1 (1) | |||
| Seizure | 4 (5) | 4 (5) | |||
| Sinus bradycardia | 1 (1) | 1 (1) | |||
| Skin and subcutaneous tissue disorders - Other, specify | 5 (6) | 1 (1) | 6 (7) | ||
| Skin hyperpigmentation | 1 (1) | 1 (1) | |||
| Somnolence | 1 (1) | 1 (1) | |||
| Stroke | 1 (1) | 1 (1) | |||
| Thromboembolic event | 2 (2) | 2 (2) | |||
| Tremor | 1 (1) | 1 (1) | |||
| Urinary frequency | 1 (1) | 1 (1) | |||
| Urinary incontinence | 1 (1) | 1 (1) | |||
| Urticaria | 1 (1) | 2 (2) | 3 (4) | ||
| Vertigo | 1 (1) | 1 (1) | |||
| Vomiting | 8 (10) | 2 (2) | 1 (1) | 11 (13) | |
| Watering eyes | 1 (1) | 1 (1) | 2 (2) | ||
| Weight loss | 1 (1) | 1 (1) | |||
| White Blood Cell Decreased | 22 (27) | 14 (17) | 5 (6) | 3 (4) | 44 (53) |