Figure 1:

Effects of prenatal kynurenine treatment on extracellular KYNA and glutamate levels in the dorsal hippocampus of adult animals. Pregnant rats were exposed to kynurenine (100 mg/day) from ED 15–22 (EKyn). ECon: control rats fed normal chow prenatally. In adulthood (PD 56–85), 30-min microdialysate samples were collected consecutively for 2 hours. Averaged individual data as well as the mean (± SEM) are shown for extracellular KYNA (N = 7–8 per group) (A) and glutamate (N = 4–5 per group) (B). Student’s t test. ** P < 0.01, *** P < 0.001.