Figure 2:

Kynurenine aminotransferase II inhibition by BFF816 (30 mg/kg, p.o.), administered 2 hours after baseline collection (arrow), results in an acute reduction in extracellular KYNA and an acute increase in extracellular glutamate levels in the rat hippocampus. Pregnant rats were exposed to kynurenine (100 mg/day) from ED 15–22 (EKyn). ECon: control rats fed normal chow prenatally. In adulthood (PD 56–85), 30-min microdialysate samples were collected from the dorsal hippocampus. Data (mean ± SEM) are shown for extracellular KYNA (N = 7–8 per group) (A) and glutamate (N = 4–5 per group) (B). Bonferroni corrected paired t test vs. basal levels. ECon: * P < 0.05; EKyn: ^# P < 0.05.