Table 1.
Recessive and dominant genes that cause monogenic SRNS, if mutated
| Gene | Protein | Accession number | Chromosome | Reference |
|---|---|---|---|---|
| Autosomal recessive | ||||
| ADCK4 | AarF domain containing kinase 4 | NM_024876.3 | 19 | [7] |
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | NM_001185078.1 | 17 | [8] |
| CD2AP | CD2-associated protein | NM_012120.2 | 6 | [9] |
| CFH | Complement factor H | NM_000186.3 | 1 | [10] |
| COQ2 | Coenzyme Q2 4-hydroxybenzoate polyprenyltransferase | NM_015697.7 | 4 | [11] |
| COQ6 | Coenzyme Q6 mono-oxygenase | NM_182476.2 | 14 | [12] |
| CRB2 | Crumbs homolog 2 | NM_173689.5 | 9 | [13] |
| CUBN | Cubilin (intrinsic factor-cobalamin receptor) | NM_001081.3 | 10 | [14] |
| DGKE | Diacylglycerol kinase, epsilon | NM_003647.2 | 17 | [15] |
| EMP2 | Epithelial membrane protein 2 | NM_001424.4 | 16 | [16] |
| FAT1 | FAT tumor suppressor homolog 1 | NM_005245.3 | 4 | |
| ITGA3 | Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | NM_005501.2 | 17 | [17] |
| ITGB4 | Integrin, beta 4 | NM_000213.3 | 17 | [18] |
| KANK1 | KN motif and ankyrin repeat domain containing protein 1 | NM_001256876.1 | 9 | [19] |
| KANK2 | KN motif and ankyrin repeat domain containing protein 2 | NM_015493.6 | 19 | [19] |
| KANK4 | KN motif and ankyrin repeat domain containing protein 4 | NM_181712.4 | 1 | [19] |
| LAMB2 | Laminin, β2 | NM_002292.3 | 3 | [20] |
| MTTL1 | Mitochondrially encoded tRNA leucine 1 | NC_012920.1 | Mito | [21] |
| MYO1E | Homo sapiens myosin IE (MYO1E) | NM_004998.3 | 15 | [22] |
| NPHS1 | Nephrin | NM_004646.3 | 19 | [23] |
| NPHS2 | Podocin | NM_014625.2 | 1 | [24] |
| NUP93 | Nucleoporin 93 kDa | NM_014669.3 | 16 | |
| NUP107 | Nucleoporin 107 kDa | NM_020401.2 | 12 | [25] |
| NUP205 | Nucleoporin 205 kDa | NM_015135.2 | 7 | |
| PDSS2 | Prenyl (decaprenyl) diphosphate synthase, subunit 2 | NM_020381.3 | 6 | [26] |
| PLCE1 | Phospholipase C, epsilon 1 | NM_016341.3 | 10 | [27] |
| PTPRO | Protein tyrosine phosphatase, receptor type, O | NM_030667.2 | 12 | [28] |
| SCARB2 | Scavenger receptor class B, member 2 | NM_005506.3 | 4 | [29] |
| SMARCAL1 | SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a- like 1 | NM_014140.3 | 2 | [30] |
| WDR73 | WD repeat domain 73 | NM_032856.2 | 15 | [31–33] |
| XPO5 | Exportin 5 | NM_020750.2 | 6 | |
| Autosomal dominant | ||||
| ACTN4 | Actinin, alpha 4 | NM_004924.4 | 19 | [34] |
| ANLN | Anillin, actin binding protein | NM_018685.2 | 7 | [35] |
| ARHGAP24 | Rho GTPase-activating protein 24 | NM_001025616.2 | 4 | [36] |
| INF2 | Inverted formin, FH2 and WH2 domain containing | NM_022489.3 | 14 | [37] |
| LMX1B | LIM homeobox transcription factor 1, beta | NM_00117414.1 | 9 | [38, 39] |
| MYH9 | Myosin heavy chain 9 | NM_002473.4 | 22 | [40] |
| TRPC6 | Transient receptor potential cation channel, subfamily C, member 6 | NM_004621.5 | 11 | [41] |
| WT1 | Wilms tumor 1 | NM_024426.4 | 11 | [42] |