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. 2018 Dec 4;36(2):328–340. doi: 10.1093/molbev/msy214

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© The Author(s) 2018. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2. — Analysis of transcriptomes of dolphin skin shows high abundance of hyperproliferation-associated keratins K6 and K17. (A) Published transcriptome data of bottlenose dolphin skin samples (n = 116; Neely et al. 2018) were analyzed for the expression levels of keratin genes. The number of RNA-seq reads were normalized to the expression level of ALAS1 as a reference gene. a.u., arbitrary units. (B–D) Schematic comparison of epidermal thickness and keratin expression in normal (B) and psoriatic (C) human epidermis and cetacean (D) epidermis. Skin sections stained with hematoxylin and eosin are shown at equal magnifications to facilitate comparison of epidermal thickness. Keratins expressed in human (according to literature cited in the main text) and dolphin skin (this study) are indicated. Keratins K6 and K17 are induced when keratinocyte hyperproliferation during wound healing or in psoriasis leads to thickening of the epidermis. Scale bars: 500 μm.