Fig. 6.

Manhattan plot of selective sweeps in the Tibetan sheep. (A) Genome-wide distribution of pairwise F_ST values between Tibetan sheep and non-Tibetan sheep computed using the Ovine SNP50K arrays (see detailed information in supplementary table S33, Supplementary Material online). The threshold value corresponding to the top 1% of the F_ST value (F_ST = 0.26) is shown as the horizontal dashed line. The black dots indicate the significant sites that harbor candidate positively selected genes. (B) Genome-wide distribution of pairwise F_ST values between Tibetan sheep and non-Tibetan sheep computed using the sequence data set (see detailed information in supplementary table S34, Supplementary Material online). (C) Distribution of log₁₀(θ_π·ratios) between non-Tibetan sheep and Tibetan sheep estimated by the sequence data set (see detailed information in supplementary table S34, Supplementary Material online). The top 5% genome-wide significant threshold values of pairwise F_ST (F_ST = 0.0846) and log₁₀(θ_{π·non-Tibetan}/θ_π·Tibetan) [log₁₀(θ_{π ratio}) = 0.1502] for the sequence data set are shown separately by black dashed lines in (B) and (C), respectively.