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. 2018 Nov 16;36(2):283–303. doi: 10.1093/molbev/msy208

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© The Author(s) 2018. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 7. — Functional enrichments of the candidate positively selected genes detected in the Tibetan sheep. (A) Word cloud summarizing 117 biological process terms with significant (P < 0.05) enrichments from the GO analysis of 747 candidate genes under positive selection in the Tibetan sheep. These GO terms are mainly related to metabolic process, biosynthetic process, transcription regulation, and nervous system development and function. (B) Proposed mechanisms of signaling pathways for hypoxia adaptation in sheep. Positively selected genes in the Tibetan sheep are indicated in purple. Pathways related to hypoxia-induced factors (HIF-1) signaling and its surrounding pathway, O₂/CO₂ exchange, and vascular smooth muscle contraction are indicated in light blue, light yellow, and light pink, respectively.