Fig. 6.

Evolution of the polypeptide exit tunnel in mitoribosomes. (A) Schematic model for formation of the new exit tunnel in the Saccharomyces cerevisiae mitoribosome starting from a bacterial precursor. Representation of the mitoribosomal components that constitute the exit tunnels of (B) Homo sapiens (PDB ID: 3J9M) and (C) S. cerevisiae (PDB ID: 3J6B). Plausible paths and detailed evolutionary events that led to the remodeling of the exit tunnel are described in supplementary figure S4, Supplementary Material online.