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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Curr Opin Behav Sci. 2018 Jul 27;23:150–159. doi: 10.1016/j.cobeha.2018.07.002

Figure 1. COMT genotype, sex, and estrogen (E) effects on cortical dopaminergic tone and cognitive task performance.

Figure 1.

Cortical dopamine tone is higher in women than men, and in individuals with the met/met vs. val/met, and val/met vs. val/val genotypes. Cortical dopamine levels affect task performance in a parabolic, task-dependent manner: performance improves with increases in dopamine tone up to an optimum that depends on task demands, and then declines.