Table 4.
Treatment sequence | Time horizon (years) | Sarilumab costs (US$) | Adalimumab costs (US$) | Incremental total costs: sarilumab vs adalimumab | ||||
---|---|---|---|---|---|---|---|---|
Drug | Routine | Total | Drug | Routine | Total | |||
Next line: csDMARD palliative treatment | 1 | $33,056 | $4,039 | $37,095 | $47,378 | $4,150 | $51,527 | −$14,432 |
5 | $95,039 | $19,278 | $114,317 | $122,202 | $19,837 | $142,039 | −$27,722 | |
10 | $140,728 | $36,248 | $176,977 | $175,063 | $37,073 | $212,136 | −$35,159 | |
Next lines: tofacitinib > csDMARD palliative treatment | 5 | $133,457 | $18,850 | $152,307 | $163,474 | $19,370 | $182,844 | −$30,537 |
10 | $195,620 | $35,776 | $231,396 | $232,544 | $36,568 | $269,112 | −$37,716 | |
Next lines: etanercept > csDMARD palliative treatment | 5 | $165,186 | $18,384 | $183,570 | $198,083 | $18,849 | $216,931 | −$33,362 |
10 | $247,966 | $34,880 | $282,847 | $288,019 | $35,603 | $323,621 | −$40,774 | |
Next lines: etanercept > tofacitinib > csDMARD palliative treatment | 5 | $188,847 | $18,122 | $206,969 | $223,368 | $18,578 | $241,946 | −$34,977 |
10 | $288,454 | $34,471 | $322,925 | $330,455 | $35,186 | $365,640 | −$42,716 |
Abbreviation: csDMARD, conventional synthetic disease-modifying antirheumatic drug.