Figure 6.

Histological analysis of bone formation in vivo.

Notes: Three days after implantation: the small, deeply stained cells adjacent to the surface of the implants were inflammatory cells infiltrating the tissues. In addition, multinucleated giant cells were scattered in the tissues. There was little difference between the two groups. Seven days after implantation: the inflammatory cells infiltrating the implant surface were significantly more numerous in the blank group than in the ASA group, and bone matrix began to appear in the ASA group. Twenty-eight days after implantation: short, cubic preosteoblasts arranged around the trabecular bone were well formed around the ASA-loaded implants; at the same time, newly formed, small blood vessels were scattered in the trabecular bone at the ASA-loaded surface.

Abbreviation: ASA, aspirin.