Table 3:

Univariate Associations of Preoperative CT Characteristics with Stage, Resection Status, and WHO Histology

CT Characteristic Presenta	IASLC/ITMIG TNM Stage OR (95% CI)	T Stage OR (95% CI)	Masaoka-Koga Stage OR (95% CI)	Resection Status OR (95% CI)	WHO Histology OR (95% CI)
Size	1.23 (0.98–1.54) p=0.08	NS	1.21 (0.98–1.50) p=0.08	NS	NS
Lobulated contour	INFb (1.75-INF) p=0.005	INFb (1.43-INF) p=0.01	6.71 (1.33–33.78) p=0.02	INFb (INF-1.03) p=0.05	NS
Heterogeneous internal density	NS	NS	NS	NS	NS
Calcification	NS	2.93 (0.86–10.05) p=0.09	NS	NS	NS
Infiltration of mediastinal fat	5.04 (1.39–18.24) p=0.014	9.97b (2.30–43.18) p=0.002	3.74 (1.05–13.31) p=0.04	8.76 (2.17–35.30) P=0.002	2.91 (0.85–9.96) p=0.09
Abutment of ≥50% of mediastinal vessels	NS	6.16 (1.49–25.53) p=0.01	NS	NS	3.15 (0.95–10.53) p=0.06
Vascular endoluminal invasion	INFb (2.92-INF) p=0.0007	INFb (3.60-INF) p=0.0003	INFb (2.92-INF) p=0.0007	INFb (5.21-INF) p<0.0001	INFb (1.22-INF) p=0.02
Abutment of adjacent mediastinal structures	NS	NS	NS	NS	NS
Invasion of adjacent mediastinal structures	6.53 (1.89–22.58) p=0.003	6.04 (1.66–22.00) P=0.006	5.97 (1.72–20.76) p=0.005	4.84 (1.26–18.65) p=0.02	NS
Elevated hemidiaphragm	INFb (2.29-INF) p=0.002	11.67b (1.03–620.72) p=0.02	INFb (2.29-INF) p=0.002	NS	NS
Pleural effusion	NS	NS	NS	NS	NS
Pleural nodule	3.78 (0.82–17.30) p=0.09	NS	NS	4.28 (0.78–23.43) p=0.09	NS
Mediastinal lymph node enlargement	NS	NS	NS	NS	NS

Abbreviations: OR=odds ratio, CI=confidence interval, cm=centimeter, NS=not significant, INF=infinity

^a=Proportional odds regression model used to determine likelihood of more advanced stage, incomplete resection status, and more aggressive WHO histology. Odds ratios that are significant (p<0.05) or trended for significance are reported (≤0.05p<0.10).

^b=Fisher’s exact test used if subgroup <6 to provide more accurate point estimate.