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. 2019 Jan 25;10(8):810–824. doi: 10.18632/oncotarget.26574

Figure 3. Association of TGFβ-EMT signature with mutations.

Figure 3

(A) Scores from the first principal component of the TGFβ-EMT signature applied to the Schabath 442 cohort are plotted for both wild-type (WT) and mutant, for four common lung adenocarcinoma mutations. Signature scores are generally lower in STK11-mutant tumors (P = 0.002) compared with WT. The other three mutations do not differ significantly from WT. (B) Genes from the TGFβ-EMT signature were used to cluster STK11 mutant patients in the TCGA database into cohorts that represent a high and low signature phenotype. These patients were then analyzed by Fisher's exact test to determine if there were mutations associated with the TGFβ phenotype that drive the STK11 mutant population. Kelch-like ECH-associated protein 1 (KEAP1), hepatocyte growth factor (HGF) ZNF831 (Zinc Finger Protein 831).