Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 25;10(8):810–824. doi: 10.18632/oncotarget.26574

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © 2019 Gordian et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

PMC Copyright notice

(A) Samples with high TGFβ-EMT signature score (red curve) exhibit significantly worse metastasis-free survival than samples with low TGFβ-EMT signature score (blue curve). (B) Magnitude of the difference in fraction survival between high (red curve) and low (blue curve) groups is similar within the early-stage subset of the cohort. (C) Kaplan–Meier metastasis-free survival analysis of the TGFβ-EMT signature in external fresh frozen Nguyen cohort [29]. Samples with high TGFβ-EMT signature score (red curve) exhibited significantly worse metastasis-free survival, although the magnitude of the difference between high (red curve) and low (blue curve) groups was smaller than in the cohort used for the TMA. (D) Differences in TGFβ-EMT signature score distributions within resected primary colon tumors. Primary tumors from patients with pre-existing metastatic disease at time of surgery (red circles) exhibit higher TGFβ-EMT signature scores than those from patients whose tumors had not metastasized (blue circles).