Figure 6. Combination of radiation and SapC-DOPS is more effective at reducing tumor size than either treatment alone.

Mice were injected subcutaneously with 1 × 10⁶ NCI-H460 cells. When tumors reached ~100 mm³, the mice were irradiated at 10 Gy as in “Materials and Methods” on days 9 and 16 following injection of the cells. SapC-DOPS (4 mg SapC/kg) was injected via the tail vein on days 11, 14, 15, 16, 17 and 18. (A) Tumors were measured with calipers and volumes were calculated as 0.52 × W × L2 where W = width and L = length of the tumor. ^*p < 0.05, ^**p < 0.01, NS = not significant. (B) The mice were euthanized on day 22 and the tumors were removed, rinsed with saline and weighed. p values from t-tests are shown. n = 4–5.