Table 1. Maternal and perinatal characteristics of enrolled neonates.
|
No IUI Group 0 n = 673 |
HCA Group 1 n = 73 |
HCA+Fun 1 Group 2 n = 34 |
HCA+Fun 2–3 Group 3 n = 27 |
P value (1 vs 0) |
P value (2 vs 0) |
P value (3 vs 0) |
|
|---|---|---|---|---|---|---|---|
|
Maternal age (mean ± SD) |
35.1 ± 6.1 | 36.3 ± 5.8 | 34 ± 5.7 | 33.4 ± 7.3 | 0.93 | 0.59 | 0.34 |
| Caucasian ethnicity (%) | 578/673 (86) | 63/73 (86.3) | 27/24 (79.4) | 14/27 (51.9) | 0.93 | 0.31 | <0.01 |
| PROM (%) | 208/673 (30.9) | 38/73 (52) | 21/34 (61.7) | 26/27 (96.3) | <0.01 | <0.01 | <0.01 |
| PROM >24 h (%) | 75/208 (36.1) | 20/38 (52.6) | 10/21 (47.6) | 18/26 (69.2) | 0.07 | 0.32 | <0.01 |
| Indicated preterm birth (%) | 389/673 (57.8) | 27/73 (37) | 2/34 (5.9) | 1/27 (3.7) | <0.01 | <0.01 | <0.01 |
| Clinical choriamnionitis (%) | 25/671 (3.7) | 11/73 (15.1) | 16/34 (47.1) | 22/27 (81.5) | <0.01 | <0.01 | <0.01 |
| Maternal antibiotics (%) | 192/673 (28.5) | 39/73 (53.4) | 20/34 (58.8) | 24/27 (88.9) | <0.01 | <0.01 | <0.01 |
| Prenatal steroids (%) | 524/671 (78.1) | 63/73 (86.3) | 25/34 (73.5) | 26/27 (96.3) | 0.14 | 0.57 | 0.05 |
| Pre-eclampsia (%) | 95/673 (14.1) | 5/73 (6.8) | 1/34 (2.9) | 0/27 | 0.09 | 0.1 | n.a. |
| Caesarean section (%) | 605/673 (90.1) | 63/73 (86.3) | 24/34 (70.6) | 16/27 (59.3) | 0.35 | <0.01 | <0.01 |
| Male (%) | 351/673 (52.1) | 46/73 (63) | 17/34 (50) | 13/27 (48.1) | 0.09 | 0.82 | 0.68 |
| SGA (%) | 115/673 (17.1) | 17/73 (23.3) | 0/34 | 0/27 | 0.18 | n.a. | n.a. |
| Twin (%) | 361/673 (53.6) | 30/73 (41.1) | 14/34 (41.2) | 4/27 (14.8) | 0.08 | 0.21 | <0.01 |
|
Gestational age (mean ± SD) |
32.3 ± 2.5 | 31.4 ± 3.1 | 28.9 ± 3.4 | 28.3 ± 3.8 | <0.01 | <0.01 | <0.01 |
|
Birth weight (mean ± SD) |
1704 ± 518 | 1492 ± 501 | 1385 ± 640 | 1235 ± 562 | <0.01 | <0.02 | <0.01 |
n.a.: not applicable