Table 3. Multivariable regression analysis of neonatal outcomes after adjustment for perinatal covariatesa, excluding gestational age.
|
Adjusted RC/ORs (1 vs 0) |
95% CI P value |
Adjusted RC/ORs (2 vs 0) |
95% CI P value |
Adjusted RC/ORs (3 vs 0) |
95% CI P value |
|
|---|---|---|---|---|---|---|
| Apgar at 1 min (points)* | -0.2 | (-0.7; 0.2) 0.3 |
-1.5 | (-2.2; -0.8) < 0.01 |
-2.2 | (-2.9; -1.4) < 0.01 |
| Apgar at 5 min (points)* | -0.2 | (-0.5; 0.1) 0.2 |
-0.7 | (-1.1; -0.3) <0.01 |
-1.2 | (-1.7; -0.7) <0.01 |
| Resuscitation at birth | 1.2 | (0.7; 2) 0.6 |
12.5 | (3.7; 41.5) <0.01 |
6.2 | (1.7; 22.2) <0.01 |
| Oxygen in delivery room | 1.4 | (0.7; 2.6) 0.3 |
7.2 | (3.3; 15.9) <0.01 |
5 | (2; 12.5) <0.01 |
| Mechanical ventilation | 0.8 | (0.4; 1.5) 0.5 |
5.4 | (2.5; 11.8) <0.01 |
3.8 | (1.6; 9.1) <0.01 |
| Mechanical ventilation (days)* | 0.6 | (-2.2; 3.5) 0.7 |
5.4 | (1.2; 9.5) 0.01 |
11.5 | (6.7; 16.2) <0.01 |
| Non-invasive ventilation | 0.9 | (0.5; 1.6) 0.75 |
2.9 | (1.3; 6.7) 0.01 |
1.8 | (0.7; 4.8) 0.2 |
| Surfactant use (overall) | 0.9 | (0.5; 1.6) 0.7 |
3 | (1.5; 5.9) <0.01 |
3.5 | (1.5; 8.3) <0.01 |
| RDS | 1.2 | (0.6; 2) 0.61 |
7.8 | (2.6; 23) <0.01 |
4.3 | (1.4; 13.5) 0.01 |
| EOS | 2.5 | (0.3; 23.4) 0.46 |
89.9 | (8.5; 100) <0.01 |
50 | (8.7; 100) <0.01 |
| LOS | 1.6 | (0.6; 4.1) 0.32 |
4.0 | (1.5; 10.9) <0.01 |
5.9 | (2; 17.9) <0.01 |
| PDA | 1.2 | (0.6; 2.5) 0.65 |
4. 1 |
(1.8; 9.1) <0.01 |
6 | (2.4; 14.7) <0.01 |
| IVH | 1.3 | (0.6; 3.5) 0.46 |
4.3 | (1.6; 11.4) <0.01 |
4.3 | (1.7; 11.4) <0.01 |
| ROP | 2.8 | (1.0; 7.8) 0.04 |
7.6 | (2.4; 24) <0.01 |
8.8 | (2.8; 27.7) <0.01 |
| BPD | 1.8 | (0.8; 3.8) 0.14 |
4.7 | (1.8: 12.8) <0.01 |
6 | (2.3; 15.8) <0.01 |
| Death before discharge | 2.0 | (0.7: 5.8) 0.17 |
7.3 | (2.3: 23.7) <0.01 |
6.3 | (1.9: 21) <0.01 |
amaternal age, ethnicity, sex, small for gestational age, antenatal steroids, indicated preterm birth
*regression coefficient (RC) has the same unit of measure of the variable