Table 4. Multivariable regression analysis of neonatal outcomes after adjustment for perinatal covariatesa, including gestational age.
|
Adjusted RC/ORs (1 vs 0) |
95% CI P value |
Adjusted RC/ORs (2 vs 0) |
95% CI P value |
Adjusted RC/ORs (3 vs 0) |
95% CI P value |
|
|---|---|---|---|---|---|---|
| Apgar at 1 min (points)* | 0 | (-0.4; 0.4) 0.99 |
-0.6 | (-1.2; -0.1) 0.05 |
-1 | (-1.7; -0.4) <0.01 |
| Apgar at 5 min (points)* | -0.1 | (-0.3; 0.2) 0.6 |
-0.1 | (-0.5; 0.2) 0.5 |
-0.5 | (-0.9; -0.1) 0.03 |
| Resuscitation at birth | 0.8 | (0.4; 1.6) 0.6 |
6.1 | (1.4; 25.3) 0.01 |
2.5 | (0.7; 8.5) 0.1 |
|
Oxygen in delivery room |
1 | (0.5; 2.1) 0.88 |
3.2 | (1; 9.3) 0.03 |
2.2 | (0.8; 5.6) 0.11 |
| Mechanical ventilation | 0.3 | (0.1; 0.7) <0.01 |
1.9 | (0.6; 6.2) 0.3 |
0.9 | (0.2; 4.5) 0.94 |
| Mechanical ventilation (days)* | -0.4 | (-3.1; 2.4) 0.8 |
0.9 | (-2.3; 4.5) 0.6 |
6.5 | (2; 11) <0.01 |
| Non-invasive ventilation | 0.7 | (0.4; 1.2) 0.2 |
1.1 | (0.3; 3.9) 0.93 |
0.6 | (0.2; 2.1) 0.46 |
| Surfactant use (overall) | 0.5 | (0.2; 0.9) 0.05 |
0.6 | (0.2;2.3) 0.59 |
1.2 | (0.4; 3.5) 0.71 |
| RDS | 0.7 | (0.4; 1.4) 0.4 |
2.8 | (0.6; 12.5) 0.17 |
1.4 | (0.4; 4.9) 0.59 |
| EOS | 2.4 | (0.3; 18.7) 0.4 |
85 | (9.4; 100) <0.01 |
37.6 | (6.7; 100) <0.01 |
| LOS | 1.2 | (0.3; 3.8) 0.8 |
0.9 | (0.3; 2.7) 0.86 |
1.2 | (0.2; 6.1) 0.83 |
| PDA | 0.6 | (0.2; 1.6) 0.3 |
0.9 | (0.3; 2.4) 0.83 |
1.8 | (0.4; 8.3) 0.44 |
| IVH | 0.8 | (0.3; 2.1) 0.65 |
1 | (0.3; 3.6) 0.9 |
0.9 | (0.2; 3.5) 0.9 |
| ROP | 3.3 | (1; 10.2) 0.04 |
2 | (0.4; 12.6) 0.4 |
1.7 | (0.3; 11) 0.59 |
| BPD | 1.5 | (0.6; 3.6) 0.42 |
1.2 | (0.3; 4.5) 0.79 |
2.2 | (0.2; 27.1) 0.57 |
| Death before discharge | 1.3 | (0.4: 4.8) 0.65 |
2 | (0.6: 7.1) 0.3 |
1.3 | (0.4: 4.7) 0.4 |
aGA, maternal age, ethnicity, sex, small for gestational age, antenatal steroids, indicated preterm birth
*regression coefficient (RC) has the same unit of measure of the variable