Fig 6. Model showing the interaction of TCTP and CSN4 and its impact on CUL neddylation and CRL complex and growth.

(a) Wild type situation. (b) Mutation of TCTP leads to enhanced deneddylation of CUL and inactivation of CRL, resulting in slower cell cycle progression and reduced growth. (c) The inverse is observed when TCTP is overexpressed. Other pathways involving CUL neddylation via CSN are not shown. CSN1-3 and CSN5-8: subunits of the Cop9 complex forming the active COP9 complex when associated with CSN4.