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. 2018 Nov 8;22(2):157–164. doi: 10.1093/ijnp/pyy091

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© The Author(s) 2018. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Influence of rhodomyrtone administration on depression-like behaviors in chronic unpredictable mild stress (CUMS). (A) Schematic of the experimental design for assessing the effect of rhodomyrtone administration in CUMS mice on depression-like behaviors. Mice were subjected to CUMS for 5 weeks. Rhodomyrtone was i.p. injected during the last 3 weeks of CUMS. Behavioral tests were conducted after exposure to the CUMS protocol. (B) CUMS mice showed less sucrose consumption than the control mice. Rhodomyrtone treatment for 3 weeks reversed the decrease of sucrose consumption in CUMS mice. (C) Rhodomyrtone treatment increased interaction time in the CUMS group. (D) Rhodomyrtone inhibited the CUMS-caused increase of immobility time in the forced swim test (FST). n=9 for all groups; data are presented as mean±SEM; *P<05; **P<.01; ***P<.001.