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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Exp Mol Pathol. 2018 Nov 25;106:27–33. doi: 10.1016/j.yexmp.2018.11.011

Figure 1.

Figure 1.

Median fold changes in non-selective ion channels in chondrocytes of CWD patients using qPCR. Pectus excavatum (PE; purple box plot) and pectus carinatum (PC; blue box plot) are shown relative to normal costal cartilage. Each sample was analyzed with an n = 3 and significant changes (p < 0.05) relative to normal costal cartilage are indicated (*). The green and red horizontal lines indicated a +2 or −2 fold change, respectively. Outlying data points in PC patients are indicated by unconnected orange dots. Genes analyzed are ASIC1, 2, and 3 Acid Sensing Ion Channel unit 1, 2, and 3; BCNG2 (HCN2) Hyperpolarization Activated Cyclic Nucleotide Gated Potassium and Sodium Channel 2; BEST1 Bestrophin; TRPC1 Transient Receptor Potential Cation Channel Subfamily C Member 1; TRPV1–4 Transient Receptor Potential Cation Channel Subfamily V Members 1–4.