Table 3:
Relationships between Tubular Markers and Intrarenal Hemodynamic Function in Adults without Type 1 Diabetes
| Variables | Non-diabetic Controls | ||||||
|---|---|---|---|---|---|---|---|
| GFRINULIN | ERPFPAH | RVR | PGLO | RA | RE | ||
| NGAL* (per ng/ml) | r: | −0.18, p=0.13 | −0.19, p=0.10 | 0.20, p=0.09 | −0.06, p=0.63 | 0.19, p=0.10 | 0.21, p=0.07 |
| β±SE**: | −13.35±6.17, p=0.03 | −88.97±38.72, p=0.02 | 30.59±11.05, p=0.007 | −0.79±0.97, p=0.42 | 1382.91±579.88, p=0.02 | 116.72±73.79, p=0.12 | |
| B2M* (per ng/ml) | r: | −0.49, p<0.0001 | −0.42, p=0.0003 | 0.34, p=0.003 | −0.22, p=0.06 | 0.30, p=0.01 | 0.18, p=0.13 |
| β±SE**: | −31.74±6.83, p<0.0001 | −160.66±45.57, p=0.0008 | 39.34±13.60, p=0.005 | −3.06±1.14, p=0.009 | 1925.51±708.20, p=0.008 | 2.09±92.98, p=0.98 | |
| OPN (per ng/ml) | r: | 0.13, p=0.27 | −0.05, p=0.69 | −0.05, p=0.67 | 0.06, p=0.64 | −0.12, p=0.33 | 0.21, p=0.08 |
| β±SE**: | 0.05±0.04, p=0.23 | −0.01±0.28, p=0.98 | −0.07±0.08, p=0.42 | 0.00±0.00, p=0.47 | −4.73±4.17, p=0.26 | 0.52±0.52, p=0.32 | |
| UMOD (per ng/ml) | r: | 0.20, p=0.09 | 0.21, p=0.08 | −0.24, p=0.05 | −0.18, p=0.13 | −0.20, p=0.09 | −0.06, p=0.62 |
| β±SE**: | 0.05±0.03, p=0.07 | 0.30±0.19, p=0.12 | −0.10±0.05, p=0.06 | −0.01±0.00, p=0.16 | −4.34±2.85, p=0.13 | −0.04±0.36, p=0.91 | |
Natural log transformed
Adjusted for age, sex, SBP and LDL
r: Correlation coefficient; β: Beta coefficient; SE: Standard error; NGAL: Neutrophil gelatinase-associated lipocalin; B2M: β-microglobulin; OPM: Osteopontin; UMOD: Uromodulin; GFR: Glomerular filtration rate; ERPF: Effective renal plasma flow; MAP: RVR: Renal vascular resistance; PGLO: Glomerular pressure; RA: Afferent arteriolar resistance; RE: Efferent arteriolar resistance.