Table 1:
BMI and hormonal changes after AGB or RYGB (Study 2 – First bariatric study)
| Months after bariatric operation | |||||
|---|---|---|---|---|---|
| Parameters | OP | 0 (a) | 3 (b) | 6 (c) | P-value |
| BMI | All | 50.2 ± 10.6b,c | 44.1 ± 8.2a | 41.4 ± 8.5a | <0.001 |
| (kg/m2) | AGB | 49.1 ± 10.5b,c | 43.3 ± 7.2a | 42.8 ± 7.8a | <0.001 |
| RYGB | 52.1 ± 11.8c | 46.3 ± 12.3 | 38.8 ± 9.9a | 0.002 | |
| Glucose | All | 88.0 (80.5, 112.5) | 93.0 (80.0, 129.0) | 87.5 (78.3, 113.8) | 0.64 |
| (mg/dl) | AGB | 88.0 (80.5, 110.5) | 99.0 (85.5, 129.0) | 102.0 (81.5, 126.5) | 0.31 |
| RYGB | 98.5 (77.3, 131.8) | 85.0 (77.0, 129.0) | 73.0 (72.0, 90.5) | 0.19 | |
| Insulin | All | 16.2 (10.8, 20.9) | 12.8 (7.9, 23.3) | 7.8 (3.7, 15.8) | 0.07 |
| (ulU/ml) | AGB | 15.1 (9.7, 19.8) | 9.5 (7.5, 23.4) | 7.9 (3.3, 17.9) | 0.42 |
| RYGB | 25.6 (12.2, 41.1)c | 16.2 (6.0, 21.3) | 4.8 (3.8, 14.5)a | 0.03 | |
| HOMA-IR | All | 2.58 (2.11, 5.13) | 2.87 (1.32, 5.22) | 1.64 (0.80, 4.98) | 0.20 |
| AGB | 2.76 (1.91, 4.93) | 2.35 (1.32, 5.72) | 1.75 (0.95. 5.81) | 0.73 | |
| RYGB | 2.58 (2.47, 11.52) | 2.99 (1.25, 3.68) | 0.84 (0.73, 3.29) | 0.07 | |
| HOMA-β | All | 218.8 (144.4, 367.4) | 111.3 (66.5, 216.8) | 110.3 (40.3, 193.0) | 0.11 |
| (%) | AGB | 188.1 (95.8, 342.6) | 117.4 (77.1, 212.4) | 47.4 (22.8, 167.7) | 0.22 |
| RYGB | 311.4 (203.9, 427.3) | 95.1 (34.6, 309.7) | 184.7 (110.3, 279.5) | 0.36 | |
| HbA1c | All | 6.00 (5.60,7.45) | 6.10 (5.65, 7.10) | 5.95 (5.43, 6.95) | 0.31 |
| (%) | AGB | 6.80 (5.60, 7.45) | 6.35 (5.95, 7.23) | 6.50 (5.60, 7.30 | 0.68 |
| RYGB | 5.95 (5.68, 7.20) | 5.80 (5.30, 6.45) | 5.50 (5.40, 6.50) | 0.13 | |
| Follistatin | All | 4.97 ± 1.03 | 4.25 ± 1.19 | 4.70 ± 1.09 | 0.07 |
| (ng/ml) | AGB | 4.94 ± 1.09 | 4.75 ± 1.22 | 4.92 ± 1.12 | 0.70 |
| RYGB | 5.03 ± 1.04b | 3.37 ± 0.33a | 4.19 ± 0.95 | 0.01 | |
| FSTL3 | All | 17.5 ± 6.1 | 16.1 ± 6.0 | 15.6 ± 5.4 | 0.14 |
| (ng/ml) | AGB | 16.9 ± 5.9 | 16.9 ± 6.8 | 16.5 ± 5.9 | 0.81 |
| RYGB | 18.6 ± 7.2 | 14.6 ± 4.2 | 14.1 ± 4.5 | 0.04 | |
†
Data are presented as mean ± SD if normally distributed and as median with first and third quartile if not normally distributed.
‡
An intention-to treat analysis was performed. P-value corresponds to the p of paired one-way ANOVA.
§
By p-value<0.05, post-hoc Tukey’s test between groups were performed. Superscript letters (a,b,c) in the table indicate p<0.05 in post-hoc t-test between the subject group of the column in which the letters are written vs. the group indicated by the letter (a, b, or c). For example for BMI All at 0 months letters b,c indicate p<0.05 in post-hoc t-test for BMI when 0 months are compared with 3 months (b) or with 6 months (c).