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20,580 compound high-throughput screen. The 20K screen, summarized in (A), yielded 115 initial hits using a standard cutoff (23.12% response, in this case) (B). After retesting and counterscreens, 51 active compounds (with IC50 < 10 μM) were identified and advanced for further testing. All of the assays performed well, yielding reasonable Z´ and signal-to-background values (C).
