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. 2019 Feb 8;9:1680. doi: 10.1038/s41598-018-38298-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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We divided the study population of 468 participants using coronary artery stenosis and circulating biomarkers. V-plots were generated for the PLS-DA-derived VIP scores versus the centred and rescaled correlation coefficients. HSPCs, neutrophils, lymphocytes and monocytes are expressed as percentages among white blood cells. HSPCs, CRP, serum triglyceride, fibrinogen and D-dimer were logarithmically transformed in the analysis. VIP represents the importance of each marker in the construction of the PLS factors. The correlation coefficients reflect the association of significant coronary stenosis (≥70%) with each marker. The markers with VIP score ≥1 and VIP score <1 are indicated in red and cyan blue, respectively.