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. 2019 Feb 8;9:1680. doi: 10.1038/s41598-018-38298-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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−Log10(p) probability plot of the multivariable-adjusted associations of various indexes of left ventricular function with the biomarkers. −Log10(p) probability plot of the multivariable-adjusted associations of various indexes of left ventricular function with the biomarkers in CHD patients. All analyses were adjusted for covariables, including age, sex, mean arterial pressure, heart rate, plasma glucose, serum creatinine, plasma glucose, γ-glutamyltransferase, smoking, alcohol intake, history of hypertension (1 or 0), history of diabetes (1 or 0), use of diuretics, inhibitors of the renin–angiotensin system (β-blockers, angiotensin-converting-enzyme inhibitors and angiotensin type1 receptor blockers), vasodilators (calcium-channel blockers and α-blockers), metformin and statins. With the exceptions of LDL-c and HDL-c, all other biomarkers were additionally adjusted with total-to-HDL-c ratio. Biomarkers in Fig. 3 as well as creatinine kinase (CK), brain natriuretic peptide (NT-pro-BNP), lactic dehydrogenase (LDH), α-hydroxybutyrate dehydrogenase (HBDH) and cardiac troponin I (TnI) were analysed and those with p < 0.05 are named here.