Table 1.

Histopathological characteristics of the different mouse groups

	Nemo	Nemo/Faslpr	Nemo/Faslpr/TNFR1−/−
Neoplasia	HCCa1	Noa2	Noa3
Anisokaryosis	4.17 ± 0.98	4.38 ± 0.51	2.88 ± 1.25c, d
Altered foci	2.17 ± 1.17	2.00 ± 1.07	0.62 + 0.91d
Mitosis/HPF (40 × )	1.75 ± 2.47	1.43 ± 0.79	0.83 ± 1.33
Cellular hypertrophy	2.5 ± 1.22	2.25 ± 0.46	1.13 ± 0.99d
Dysplasia	2.5 ± 1.27	2.30 ± 0.46	1.00 ± 0.93d
Oval cell proliferation	2.17 ± 0.98	1.5 ± 0.53	0.87 ± 0.64c, d
Lymphoid aggregates/lymphocytic inflammation	0.50 ± 0.00	1.00 ± 0.00	0.86 ± 0.89
Apoptosis	1.50 ± 0.70	1.28 ± 0.48	0.67 ± 0.51
Additional lesions	Mild lipidosis diffuse vaculopathy	Multifocal necrosis	Biliary atresia early lymphomas

^a1Well-differentiated trabecular or solid HCCs

^a2Early hepatocellular adenomas

^a3Single well-differentiated trabecular and glandular HCC

^cNemo versus Nemo/Fas^LPR/TNFR1^−/−

^dNemo/Fas^LPR versus Nemo/Fas^LPR/TNFR1^−/−