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. 2019 Feb 8;10:654. doi: 10.1038/s41467-019-08415-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Effect of reversion mutations on neutralization potency and breadth. a Antibody neutralization of the wild-type and reversion mutants of the CH103 lineage intermediate I4 and the CH103 bnAb against autologous and heterologous Env-pseudoviruses. b Antibody neutralization of the wild-type and reversion mutants of the DH270 lineage intermediate I2 and the DH270.2 bnAb against autologous and heterologous Env-pseudoviruses. Antibody neutralization was measured by a TZM-bl cell-based assay using a select panel of geographically and genetically diverse Env-pseudoviruses. All values are IC₅₀ (µg/mL) unless otherwise noted