Table 3.
BnAb elbow region mutation frequencies
| bnAb | Epitope | % FWR | % Elbow | VH Elbow Mutations | VH*** | VH* | VH |
|---|---|---|---|---|---|---|---|
| 8ANC131 | CD4 BS | 31 | 42.9 | A9G,E10G*,V11L***,T107S,T110I***,S112T*** | 3 | 1 | 6 |
| CH103 | CD4 BS | 20.7 | 42.9 | L11V***,P14S,T107S,T110S***,S112T***,S113A* | 3 | 1 | 6 |
| VRC13.01 | CD4 BS | 44.8 | 57.1 | A9T,E10A*,V11M***,K13S,P14L,L108F,T110R***,S113P* | 2 | 2 | 8 |
| N6 | CD4 BS | 31 | 42.9 | A9T,E10A*,V11M***,M108T,T110V***,S113A* | 2 | 2 | 6 |
| VRC01 | CD4 BS | 34.5 | 35.7 | A9G,E10Q*,V11M***,L108P,T110I*** | 2 | 1 | 5 |
| VRC16.01 | CD4 BS | 19.5 | 28.6 | L11F***,Q13K,T110I***,S113A* | 2 | 1 | 4 |
| CH235.12 | CD4 BS | 36.8 | 50 | A9G,E10G*,K13R,P14L,T107S,L108P,T110I*** | 1 | 1 | 7 |
| VRC27.01 | CD4 BS | 34.5 | 35.7 | A9P,E10Q*,K12R*,L108R,T110V*** | 1 | 2 | 5 |
| VRC-CH31 | CD4 BS | 29.9 | 28.6 | E10A*,K12R*,L108P,T110V*** | 1 | 2 | 4 |
| VRC18.02 | CD4 BS | 29.9 | 28.6 | A9N,E10Q*,K12R*,T110I*** | 1 | 2 | 4 |
| NIH45-46 | CD4 BS | 35.6 | 35.7 | A9G,E10Q*,V11M***,T107A,L108P | 1 | 1 | 5 |
| 1B2530 | CD4 BS | 32.2 | 28.6 | A9T,E10A*,K12R*,T107S | 0 | 2 | 4 |
| 3BNC117 | CD4 BS | 28.7 | 21.4 | E10A*,K12T*,L108Q | 0 | 2 | 3 |
| 3BNC60 | CD4 BS | 32.2 | 21.4 | E10A*,K12T*,L108Q | 0 | 2 | 3 |
| 8ANC195 | gp120-gp41 | 35.6 | 28.6 | A9T,V109I*,T110S***,S113A* | 1 | 2 | 4 |
| 35O22 | gp120-gp41 | 26.4 | 14.3 | V11L***,V109L* | 1 | 1 | 2 |
| PGT151 | gp120-gp41 | 16.1 | 0 | – | 0 | 0 | 0 |
| VRC34 | gp41 | 19.5 | 7.1 | T108S | 0 | 0 | 1 |
| DH511.2 | MPER | 19.5 | 7.1 | T110I*** | 1 | 0 | 1 |
| 2F5 | MPER | 11.5 | 21.4 | T10P*,T107I,V111I* | 0 | 2 | 3 |
| 4E10 | MPER | 10.3 | 7.1 | K13R | 0 | 0 | 1 |
| 10E8 | MPER | 20.7 | 0 | – | 0 | 0 | 0 |
| PGDM1400 | Glycan V1/V2 | 32.2 | 21.4 | A9P,K12R*,T108A | 0 | 1 | 3 |
| PGT145 | Glycan V1/V2 | 20.7 | 7.1 | T108A | 0 | 0 | 1 |
| PG9 | Glycan V1/V2 | 13.8 | 0 | – | 0 | 0 | 0 |
| CH01 | Glycan V1/V2 | 26.4 | 21.4 | G9A,G10N*,T110S*** | 1 | 1 | 3 |
| BF520 | Glycan V3 | 5.7 | 21.4 | V11M***,K13M,T110S*** | 2 | 0 | 3 |
| DH270.6 | Glycan V3 | 17.2 | 28.6 | E10Q*,V11M***,K13N,V109L* | 1 | 2 | 4 |
| PGT128 | Glycan V3 | 24.1 | 21.4 | G10T*,K13E,P14A | 0 | 1 | 3 |
| PGT135 | Glycan V3 | 21.8 | 14.3 | T107V,L108Q | 0 | 0 | 2 |
| PGT121 | Glycan V3 | 20.7 | 7.1 | T108Q | 0 | 0 | 1 |
| 2G12 | Glycan V3 | 29.9 | 21.4 | P14A,M108V,S113* | 0 | 1 | 3 |
VH framework and elbow region mutation frequencies (%) are relative to the unmutated common ancestor. Asterisks indicate whether residues occur in the ball-and-socket (***) or are ball-and-socket adjacent (*). The VH list includes all residues in the elbow region.