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. 2019 Feb 8;10:687. doi: 10.1038/s41467-019-08604-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Genes and pathways associated with innateness. a Volcano plot showing associations with the innateness gradient. Yellow, genes with P < 0.05; red, genes with P < 2.5e–06 (Bonferroni threshold); blue, genes with GO terms involving NK-mediated immunity and cellular defense response (GO:0006968, GO:0002228). b Innateness level (β) for individual genes in a with P < 2.5e–06. c As in a but with blue showing genes from GO terms involving leukocyte chemotaxis and migration (GO:2000501, GO:0035747, GO:1901623, GO:0030595, GO:2000401, GO:0097530, GO:0097529, GO:0048247, GO:0072676, GO:1990266). d Innateness level (β) for individual genes in c with P < 2.5e–06. e GZMB and f PRF1 flow-cytometric validation, showing protein levels (x-axis), and transcript levels with RNA-seq (y-axis)