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Selected parameters for the experimental domain.
| Factor | Low level (−) | Centre point (0) | High level (+) |
|---|---|---|---|
| A Pressure (bar) | 85 | 150 | 250 |
| B Temperature (°C) | 35 | 43 | 50 |
| C Processing time (min) | 30 | 120 | 180 |
| D Material (g) | 1 | 3 | 5 |
| E Sonication time (min) | absent | 15 | 30 |
| F Stirring rate (rpm) | absent | 200 | 450 |
