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. 2019 Feb 8;9:1692. doi: 10.1038/s41598-018-37119-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Disease proto-modules separation and connections. (A) Significance of topological relationships between axonopathy proto-modules (Charcot-Marie-Tooth type 2 only: CMT2; Hereditary Spastic Paraplegia only: HSP; combined HSP + CMT2) and control diseases (Cancer: CA, Deafness: DFN, Cardiomyopathy: CM, Muscular Dystrophy: MD, Parkinson’s Disease: PD, Amyotrophic Lateral Sclerosis: ALS, and Hereditary Ataxia: ATX). Gray dotted lines indicate the threshold for significance (|Z-scores| >=1.6). Negative (positive) Z-scores indicate overlapped (separated) modules. (B) Direct connections between HSP + CMT2 disease proteins and comparison disease proteins. Disease names and input seed protein count (highlighted by red bar) for each disease compared are indicated outside the circle. Direct interactions between disease proteins of HSP + CMT2 are displayed on the outer gray bar (highlight by orange bar).