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. 2019 Feb 8;10(2):112. doi: 10.1038/s41419-019-1390-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Based on JASPAR database, the putative score of YY1 binding to miR-1260b was the highest. b ChIP assay indicated the YY1 binds to the putative binding site upstream of miR-1260b. c The effect of knockdown YY1 by siRNA was identified by qRT-PCR. d, e Levels of miR-1260b and SOCS6 responding downregulated YY1 were detected by qRT-PCR. f, g CCK-8 and flow cytometric assays were the influence of downregulated YY1 on cell proliferation and apoptosis respectively. h, i The relative expression level of miR-1260b or SOCS6 was accessed by qRT-PCR after co-transfection si-YY1 with Lv-miR-1260b or Lv-vector. j, k Cell proliferation and cell apoptosis was determined after co-transfected with si-YY1 and Lv-miR-1260b or Lv-vector. The data expressed as the mean ± SD (*P < 0.05; **P < 0.01; ***P < 0.001)