Table 3.
Univariate Cox regression for the prediction of 28-day mortality in the derivation and validation cohorts
| Biomarker or clinical score | Patients (N) | Mortality (N) | LR χ2 | DF | p value | C-index | HR IQR [95% CI] |
|---|---|---|---|---|---|---|---|
| Derivation cohort | |||||||
| MR-proADM | 1175 | 84 | 166.4 | 1 | < 0.001 | 0.869 | 5.4 [4.2–6.9] |
| PCT | 1166 | 84 | 42.4 | 1 | < 0.001 | 0.713 | 2.1 [1.7–2.6] |
| Lactate | 746 | 59 | 25.3 | 1 | < 0.001 | 0.678 | 2.2 [1.6–2.9] |
| CRP | 1170 | 83 | 19.7 | 1 | < 0.001 | 0.649 | 2.5 [1.6–3.8] |
| SIRS | 965 | 84 | 12.2 | 1 | < 0.001 | 0.640 | 1.9 [1.3–2.8] |
| SOFA | 1175 | 84 | 83.5 | 1 | < 0.001 | 0.827 | 2.6 [2.2–3.1] |
| qSOFA | 1175 | 84 | 73.4 | 1 | < 0.001 | 0.836 | 3.2 [2.5–4.0] |
| NEWS | 1058 | 81 | 53.0 | 1 | < 0.001 | 0.734 | 3.1 [2.3–4.2] |
| CRB-65 | 1175 | 84 | 75.8 | 1 | < 0.001 | 0.838 | 2.6 [2.1–3.2] |
| Validation cohort | |||||||
| MR-proADM | 896 | 45 | 84.2 | 1 | < 0.001 | 0.881 | 3.8 [2.9–5.0] |
| PCT | 884 | 45 | 32.4 | 1 | < 0.001 | 0.770 | 2.0 [1.6–2.5] |
| CRP | 780 | 42 | 19.4 | 1 | < 0.001 | 0.703 | 3.1 [1.7–5.6] |
CI confidence interval, CRB-65 severity score for community-acquired pneumonia, CRP C-reactive protein, DF degrees of freedom, HR hazard ratio, IQR interquartile range, LR likelihood ratio, MR-proADM mid-regional proadrenomedullin, N number, NEWS National Early Warning Score, PCT procalcitonin, qSOFA quick Sequential Organ Failure Assessment, SIRS systemic inflammatory response syndrome, SOFA Sequential Organ Failure Assessment