Fig. 1.

Diagram of NR3C1: the human glucocorticoid receptor (hGR) gene. a The hGR gene, NR3C1, is located on Chromosome 5q31–32 and is composed of one untranslated exon (exon 1) and eight coding exons (2–9). Alternative splicing of exon 9 results in two isoforms, hGRα and hGRβ, and the splice junction is indicated with a vertical dashed line. Relative intron (A → H) locations are shown above the gene. b hGRα, the biologically active isoform, codes for a 777 amino acid protein that is made up of four domains: transactivation domain, DNA-binding domain (DBD), hinge region (H), and ligand-binding domain (LBD). hGRβ arises from alternative splicing of exon 9 to produce a 742 amino acid protein where the last fifteen amino acids differ from hGRα. Shaded areas in the exons match the different domains. Start and stop codons are indicated on the coding sequence with vertical lines