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. 2019 Feb 9;18:46. doi: 10.1186/s12944-019-0993-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Synergistic inhibitory effect of the combination of TVA and S63845 on NPC cells. a. Cell viability of NPC cells after treatment with TVA (25, 50, 75, 100 and 125 μM), S683845 (1, 2, 3, 4 and 5 μM) or a combination of TVA and S63845 in a fixed ratio of 25:1 (TVA:S63845) for 24 h. b. CI value of the TVA/S63845 combination at each fixed ratio concentration. c. Signaling pathways underlying TVA and/or S63845-induced apoptosis in NPC cells