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. 2019 Feb 8;16:29. doi: 10.1186/s12974-019-1421-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The increased expression of Nav1.6 in DRG was involved in L5-VRT-induced mechanical allodynia. a The hind paw withdraw threshold was substantially reduced by L5-VRT in rats. n = 12 per group, **P < 0.01 versus the sham group. b The expression of Nav1.6 mRNA was significantly increased following L5-VRT. n = 5 per group, **P < 0.01 versus the sham group. c Representative blots and histogram showed the effect of L5-VRT on Nav1.6 protein. n = 5 per group, **P < 0.01 versus the sham group. d The immunofluorescence staining showed the colocalization of Nav1.6 with IB4 and NF-200, but not GFAP, in DRG. n = 3 per group, Scale bar, 50 μm. e Application of Nav1.6 shRNA significantly attenuated L5-VRT-induced mechanical allodynia. n = 12 per group, **P < 0.01 versus the sham group, ##P < 0.01 versus the corresponding L5-VRT group