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Sema4A causes apoptosis in mature myelinating oligodendrocytes in vivo. a Infusion of Sema4A into the corpus callosum results in increased TUNEL staining, indicating increased levels of apoptosis, relative to the uninjected regions as well as the PBS control. b Sema4A treatment results in increased levels of cleaved caspase-3 relative to the uninjected and PBS-injected regions
