Table 1.
Global Distribution of Reviewed ATTR-PN Cases, n (%)
| Country | Country Total | Ala97Ser | Phe64Leu | Ser77Tyr | Val30Met | Other |
|---|---|---|---|---|---|---|
| France | 97 (17.9%) | 0 (0%) | 0 (0%) | 33 (34%) | 47 (48.5%) | 17 (17.5%) |
| Japan | 92 (17%) | 0 (0%) | 0 (0%) | 0 (0%) | 76 (82.6%) | 16 (17.4%) |
| China | 71 (13.1%) | 2 (2.8%) | 0 (0%) | 12 (16.9%) | 23 (32.4%) | 34 (47.9%) |
| Italy | 58 (10.7%) | 0 (0%) | 24 (41.4%) | 0 (0%) | 21 (36.2%) | 13 (22.4%) |
| Taiwan | 35 (6.5%) | 33 (94.3%) | 0 (0%) | 1 (2.9%) | 0 (0%) | 1 (2.9%) |
| Germany | 26 (4.8%) | 0 (0%) | 0 (0%) | 0 (0%) | 13 (50%) | 13 (50%) |
| Spain | 19 (3.5%) | 0 (0%) | 0 (0%) | 0 (0%) | 8 (42.1%) | 11 (57.9%) |
| Portugal | 18 (3.3%) | 0 (0%) | 0 (0%) | 0 (0%) | 16 (88.9%) | 2 (11.1%) |
| Greece | 17 (3.1%) | 0 (0%) | 0 (0%) | 0 (0%) | 17 (100%) | 0 (0%) |
| Israel | 17 (3.1%) | 0 (0%) | 0 (0%) | 8 (47.1%) | 4 (23.5%) | 5 (29.4%) |
| Sweden | 14 (2.6%) | 0 (0%) | 0 (0%) | 0 (0%) | 5 (35.7%) | 9 (64.3%) |
| Ireland | 12 (2.2%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 12 (100%) |
| Argentina | 11 (2%) | 0 (0%) | 0 (0%) | 0 (0%) | 8 (72.7%) | 3 (27.3%) |
| Turkey | 11 (2%) | 0 (0%) | 0 (0%) | 0 (0%) | 4 (36.4%) | 7 (63.6%) |
| Brazil | 8 (1.5%) | 0 (0%) | 0 (0%) | 0 (0%) | 8 (100%) | 0 (0%) |
| United States | 6 (1.1%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (16.7%) | 5 (83.3%) |
| Australia | 3 (0.6%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 3 (100%) |
| Belgium | 3 (0.6%) | 0 (0%) | 0 (0%) | 0 (0%) | 3 (100%) | 0 (0%) |
| Finland | 3 (0.6%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 3 (100%) |
| Poland | 3 (0.6%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 3 (100%) |
| Romania | 3 (0.6%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 3 (100%) |
| Korea (South) | 2 (0.4%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 2 (100%) |
| Russia | 2 (0.4%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 2 (100%) |
| Slovenia | 2 (0.4%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 2 (100%) |
| Switzerland | 2 (0.4%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (50%) | 1 (50%) |
| Czech Republic | 1 (0.2%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (100%) |
| Denmark | 1 (0.2%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (100%) | 0 (0%) |
| Holland | 1 (0.2%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (100%) | 0 (0%) |
| India | 1 (0.2%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (100%) |
| Malaysia | 1 (0.2%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (100%) |
| Norway | 1 (0.2%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (100%) | 0 (0%) |
| United Kingdom | 1 (0.2%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (100%) |
| Genotype Total | 542 (100%) | 35 (6.5%) | 24 (4.4%) | 54 (10%) | 258 (47.6%) | 171 (31.5%) |
Specific genotypes shown are those with ≥4% representation among the included cases. Genotypes with < 4% representation are listed as “Other”. Refer to Additional file 1: Appendix A for a list of genotypes included in the “Other” category