Table 3.
Group | Week 0 | Week 1 | Week 2 | Week 3 | Week 4 |
---|---|---|---|---|---|
WKY + saline | 21.66 ± 2.67 | 19.47 ± 2.24 | 15.16 ± 2.27 | 12.55 ± 1.63 | 9.78 ± 2.75 |
SHR + saline | 43.84 ± 2.39## | 42.18 ± 2.03## | 40.04 ± 2.35## | 39.60 ± 2.22## | 40.51 ± 1.79## |
SHR + MPH(1.5 mg/kg) | 46.34 ± 3.13 | 26.66 ± 2.67** | 21.14 ± 2.30** | 17.69 ± 2.46** | 12.23 ± 2.22** |
SHR + baicalin(50 mg/kg) | 45.06 ± 1.48 | 41.57 ± 1.75 | 38.89 ± 2.71 | 29.12 ± 2.57* | 23.41 ± 2.87** |
SHR + baicalin(100 mg/kg) | 44.89 ± 3.42 | 41.01 ± 2.82 | 31.64 ± 2.58* | 26.77 ± 1.90** | 21.19 ± 3.48** |
SHR + baicalin(150 mg/kg) | 46.48 ± 2.80 | 33.24 ± 1.75* | 24.54 ± 1.63** | 17.52 ± 1.76** | 14.26 ± 2.83** |
Note: Comparison of the moving distance in the open field test in all groups; values are expressed as the mean ± S.E.M. #p < 0.05 and ##p < 0.01 versus WKY + saline group; *p < 0.05 and **p < 0.01 versus SHR + saline group